13.6.2.2 Sympathomimetics

MHRA Advice Summaries:
1. Warn patients not to apply brimonidine gel to irritated or damaged skin, including after laser therapy to the skin due to risk of systemic cardiovascular effect.
2. Initiate treatment with a small amount of gel and increase the dose gradually to avoid exacerbation or rebound symptoms of rosacea.
3. Initiate treatment with a small amount of gel for at least 1 week and increase the dose gradually, based on tolerability and response to treatment.
4. Advise patients carefully on how to apply the gel and on the importance of not exceeding the maximum daily dose.